ceesdekker.net Secrets
ceesdekker.net Secrets
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‘The next is nanopores, that's our oldest line of investigation and which has now brought about DNA sequencers dependant on nanopores. We pull unique DNA strands via a nanopore and might then read through off the nucleotide sequence. Really not too long ago, we even managed to go through out just one protein for the first time using This system. But this line of exploration is don't just about producing equipment, but additionally about true biological questions.
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
[Laughs] ‘It had been absolutely a terrific danger! At the time, I had been perfectly informed that it could go Erroneous and that I could grow to be much less successful, but I just disregarded that. Curiosity has normally been my strongest driving pressure. And by chance it all labored out.’
2007, very first serious-time detection of strand exchange in homologous recombination by RecA; discovery of a very low persistence duration of ends of microtubules; and settled the system of biosensing with carbon nanotubes
2015, discovery that condensin can be a very flexible protein framework; and very first detection of DNA knots using nanopores
During the decades next these discoveries, my exploration passions shifted to biophysics and nanobiology, And that i became less linked to the event of nanotube electronics. The main focus of many scientists in the sector also shifted to graphene (exactly where, funnily enough, the main graphene ribbons ended up referred to as ‘nanotubes which are cut open up along their duration’) soon after the discovery of The 2-dimensional content in 2004.
We shape microbes into sorts that deviate from their pure phenotype. Specially, I will display our ability to condition Stay E. coli microorganisms into novel shapes such as rectangles, squares, triangles and circles.
Illustration (one) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is revealed in grey, the rim of the pore is highlighted in purple, along with a 3D rendering with the motion on the DNA rod is displayed.
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1). The existing–voltage curves showed sizeable modulations with gate voltage, even at space temperature, which was according to band bending within a ~0.six eV bandgap semiconducting nanotube. These knowledge also confirmed that the conductance may very well be modulated by six orders of magnitude by shifting the gate voltage. The results of this do the job — a space-temperature transistor constructed from a single carbon nanotube molecule — ended up posted in Nature in May possibly 1998.
[fourteen] In 2005 Dekker became associated with Netherlands-large discussions about Smart Design, a movement that he has considering the fact that Obviously distanced himself from. Dekker advocates that science and faith are not in opposition but might be harmonized.
Cees Dekker is Distinguished University Professor at TU Delft. Skilled like cees dekker a physicist, he pioneered nanotechnology with several discoveries on carbon nanotubes inside the 1990s. Because 2000, he moved to single-molecule biophysics and nanobiology. His current research concentrates on (i) nanopores for protein sequencing; (ii) chromosome composition, specifically SMC motor protein; and (iii) creating a living synthetic mobile from lifeless molecules. Dekker is really an elected member on the KNAW and fellow on the APS as well as the IOP.
Developments in nanotechnology from the 1990s built setting up Digital units from single molecules a possibility. Cees Dekker recounts how his workforce made a area-temperature transistor depending on a single carbon nanotube.
Supercoiling-dependent DNA binding: quantitative modeling and purposes to bulk and single-molecule experiments